PHO Microbiology Rounds: Fishing for Antimicrobial Resistance (AMR): A Metagenomic Platform for Antimicrobial Surveillance
Surveillance of antimicrobial resistance is a complex challenge that requires innovation to exploit new technologies in the modern genomic era. Next-generation nucleic acid sequencing offers a powerful approach to identify resistance and related elements in various samples. One of the challenges of such methods is that in complex metagenomes, antimicrobial resistance genes represent only a small fraction of the genomic material, which results in costly over-sequencing of unrelated sequences.
We have developed a Bait-and-Capture method to sample complex metagenomes for all known antibiotic resistance genes. This platform and its use in longitudinal studies of antibiotic use in various cohorts and new approaches in wastewater sampling will be presented. The Bait-and-Capture method can be readily adapted to interrogate complex systems for the presence of target genes, making it a powerful tool in infectious disease surveillance.
Intended audience: Biomedical and clinical researchers and technical staff.
Presenter(s): Gerry Wright
Gerry Wright PhD, FRS, is the Lead of Canada’s Global Nexus for Pandemics & Biological Threats at McMaster University. He was the founding Director of the Michael G. DeGroote Institute for Infectious Disease Research (2007-2022). Dr. Wright researches the mechanisms of antimicrobial resistance and the discovery and development of new antimicrobial therapies. He has studied resistance mechanisms of many antibiotics, including glycopeptides, aminoglycosides, macrolides, beta-lactams, tetracyclines, and others. His group coined the term the “Antibiotic Resistome”, a framework that explains the broad distribution of antimicrobial resistance elements. His team has discovered several new antibiotics, antifungals, antimalarials, and inhibitors of antibiotic resistance
Disclaimer
The opinions expressed by speakers and moderators do not necessarily reflect the official policies or views of Public Health Ontario, nor does the mention of trade names, commercial practices, or organizations imply endorsement by Public Health Ontario.
Accreditation
Public Health Ontario Rounds are a self-approved group learning activity (Section 1) as defined by the Maintenance of Certification Program of the Royal College of Physicians and Surgeons of Canada (RCPSC). In order to receive written documentation for Continuing Medical Education (CME) credits, please check “Yes” beside the question “Do you require CME credits?” on the registration form.
College of Family Physicians of Canada (CFPC) Affiliate Members may count RCPSC credits toward their Mainpro+ credit requirements. All other CFPC members may claim up to 50 Certified credits per cycle for participation in RCPSC MOC Section 1 accredited activities.
PHO Rounds are also approved by the Council of Professional Experience for professional development hours (PDHs) for members of the Canadian Institute of Public Health Inspectors (CIPHI).
For more information or for a record of registration for other Continuing Education purposes, please contact capacitybuilding@oahpp.ca.
Accessibility
Public Health Ontario is committed to complying with the Accessibility for Ontarians with Disabilities Act (AODA). If you require accommodations to participate in this event, please contact 647-260-7100 or capacitybuilding@oahpp.ca.
Register Here
